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Research

Microcephaly in Australian infants: A retrospective audit

The aim of this study was to describe clinical characteristics, outcomes and causes of microcephaly in children whose condition was identified within the first year of life.

Environment & Lifestyle

Interventions and explorations that focus on modifiable elements of the early life environment are being investigated, to assess and improve all aspects of physical and psychological wellbeing - both in childhood and in later life. These include nutrition, physical activity, time in nature, built environments, plastics and pollutants.

Oral Health

Tooth decay remains one of the most common diseases in young children. It can cause pain and infection and, if it remains untreated, can affect eating, speech, and sleep in children. Researchers are exploring the importance of early intervention and education for child dental health outcomes.

CEED: Colostrum Exclusivity in Early Development

Research shows at least a third of newborns receive formula in hospital, a practice shown to be associated with an increased risk of cow’s milk allergy.

CEED: Colostrum Exclusivity in Early Development

Research shows at least a third of newborns receive formula in hospital, a practice shown to be associated with an increased risk of cow’s milk allergy.

The Mediterranean Diet

This study aims to examine how a Mediterranean diet and exercise in pregnancy impacts on neonatal body fat composition at birth and weight at one year of age.

IRON Child

One in three children in WA suffer iron deficiency leading to poor sleep, fussy eating, and behavioural difficulties. This project aims to develop mechanisms to prevent and treat the problems before they become clinically significant and translate findings to other communities to improve childhood wellness.

Research

Ion channel modulator DPI-201-106 significantly enhances antitumor activity of DNA damage response inhibitors in glioblastoma

Glioblastoma, a lethal high-grade glioma, has not seen improvements in clinical outcomes in nearly 30 years. Ion channels are increasingly associated with tumorigenesis, and there are hundreds of brain-penetrant drugs that inhibit ion channels, representing an untapped therapeutic resource. The aim of this exploratory drug study was to screen an ion channel drug library against patient-derived glioblastoma cells to identify new treatments for brain cancer. 

Research

Effects of pregnancy and lactation prebiotics supplementation on infant allergic disease: A randomized controlled trial

Ingestion of prebiotics during pregnancy and lactation may have immunomodulatory benefits for the developing fetal and infant immune system and provide a potential dietary strategy to reduce the risk of allergic diseases. We sought to determine whether maternal supplementation with dietary prebiotics reduces the risk of allergic outcomes in infants with hereditary risk.

Research

Prevalence, distribution, and inequitable co-occurrence of mental ill-health and substance use among gender and sexuality diverse young people in Australia: epidemiological findings from a population-based cohort study

To estimate the prevalence, distribution, and co-occurrence of mental ill-health and substance use among gender and sexuality diverse young people relative to their cisgender and heterosexual peers in Australia using population-level, nationally representative data.