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Research
Standardizing clinical care measures of rheumatic heart disease in pregnancy: A qualitative synthesisPregnancy provides an opportunity to strengthen health system responses and address whole-of-life health for women with rheumatic heart disease
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Upper Airway Pathology Contributes to Respiratory Symptoms in Children Born Very PretermThe upper airway may play a role in the respiratory symptoms experienced by some very preterm children and should be considered by clinicians
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The Use of Test-negative Controls to Monitor Vaccine Effectiveness: A Systematic Review of MethodologyOur review highlights similarities and differences in the application of the test-negative design that deserve further examination
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Mental-health disparities between heterosexual and sexual-minority adolescents: Examining the role of informant discrepanciesUnderstanding informant discrepancies and their meaning is pivotal to designing surveys that generate robust insights into the health of sexual-minority adolescents
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S. aureus colonization in healthy Australian adults receiving an investigational S. aureus 3-antigen vaccineBased on descriptive analyses of this small study, S. aureus 3-antigen vaccine vaccination did not impact S. aureus acquisition or carriage
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A cross-sectional examination of the clinical significance of autistic traits in individuals experiencing a first episode of psychosisResults suggest that autism traits are associated with poorer clinical presentation in first-episode psychosis populations
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Pleural Plaques and the Risk of Lung Cancer in Asbestos-exposed SubjectsThe presence of pleural plaques on radiologic imaging does not confer additional increase in the risk of lung cancer
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Modelling the effects of beverage substitution during adolescence on later obesity outcomes in early adulthood: Results from the raine studySugar-sweetened beverage intake during adolescence was associated with higher body mass index, waist circumference, and being overweight in early adulthood
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Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastomaMedulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by radiotherapy and cytotoxic chemotherapy. Despite this intensive approach, outcome remains dismal for patients with certain subtypes of MB, namely, MYC-amplified Group 3 and TP53-mutated SHH. Using high-throughput assays, six human MB cell lines were screened against a library of 3208 unique compounds. We identified 45 effective compounds from the screen and found that cell cycle checkpoint kinase (CHK1/2) inhibition synergistically enhanced the cytotoxic activity of clinically used chemotherapeutics cyclophosphamide, cisplatin, and gemcitabine.
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Overcoming the challenges of caring for a child with foetal alcohol spectrum disorder: a Pilbara community perspectiveThe caregivers in this study have gained valuable knowledge and wisdom through caring for a child with FASD