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Copeptin Kinetics and Its Relationship to Osmolality During Rehydration for Diabetic Ketoacidosis in ChildrenCopeptin is a surrogate marker for arginine vasopressin (AVP) release in response to hyperosmolal stimuli such as diabetic ketoacidosis (DKA). The objective of this work is to characterize kinetics of copeptin and osmolality, and their dynamic relationship during rehydration and insulin therapy in children with type 1 diabetes (T1D) and DKA.
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Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systemsWe conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study.
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Durvalumab with first-line chemotherapy in previously untreated malignant pleural mesothelioma (DREAM): a multicentre, single-arm, phase 2 trial with a safety run-inThere is a strong unmet need to improve systemic therapy in mesothelioma. Chemotherapy with cisplatin and pemetrexed improves survival in malignant pleural mesothelioma, and immune checkpoint inhibitors are an emerging treatment in this disease. We aimed to evaluate the activity of durvalumab, an anti-PD-L1 antibody, given during and after first-line chemotherapy with cisplatin and pemetrexed in patients with advanced malignant pleural mesothelioma.
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Decreased Physical Working Capacity in Adolescents With Nonalcoholic Fatty Liver Disease Associates With Reduced Iron AvailabilityIn a well-defined cohort of adolescents, we found non-alcoholic fatty liver disease to be associated with decreased cardiorespiratory fitness, independent of BMI
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Validation of the Dutch version of the Multidimensional Adolescent Functioning Scale (MAFS)The Multidimensional Adolescent Functioning Scale (MAFS) is a 23-item, self-report questionnaire assessing psychosocial functioning in adolescents aged 12-17 years. It captures three domains of functioning: 'general functioning', 'family-related functioning', and 'peer-related functioning'. The original English version has good psychometric properties. The aim of the current paper was to translate the MAFS to Dutch and to investigate the psychometric properties of this translation.
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Associations between biological and sociodemographic risks for developmental vulnerability in twins at age 5: a population data linkage study in Western AustraliaTo investigate the prevalence of, and associations between, prenatal and perinatal risk factors and developmental vulnerability in twins at age 5.
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Does perinatal exposure to exogenous oxytocin influence child behavioural problems and autistic-like behaviours to 20 years of ageThis study is the first to investigate longitudinal mental health outcomes associated with the use of oxytocin-based medications during labour
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A randomized comparison of three prandial insulin dosing algorithms for children and adolescents with Type 1 diabetesThe Pankowska Equation resulted in reduced postprandial hyperglycaemia at the expense of an increase in hypoglycaemia
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A Comparison of the Motor Skills of Young People in a Youth Detention Centre with Diagnosed Fetal Alcohol Spectrum Disorder and Prenatal Alcohol ExposureVisual motor integration and handwriting skills were often impaired in this population of young people in a youth detention centre
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Exposure to Ultraviolet Radiation in the Modulation of Human DiseasesThis review focuses primarily on the beneficial effects for human health of exposure to ultraviolet radiation