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Research
Presence of onco-fetal neighborhoods in hepatocellular carcinoma is associated with relapse and response to immunotherapyOnco-fetal reprogramming of the tumor ecosystem induces fetal developmental signatures in the tumor microenvironment, leading to immunosuppressive features. Here, we employed single-cell RNA sequencing, spatial transcriptomics and bulk RNA sequencing to delineate specific cell subsets involved in hepatocellular carcinoma relapse and response to immunotherapy.
Research
Outcomes following intensive day rehabilitation for young people in Western AustraliaIntensive rehabilitation aims to improve and maintain functioning in young people who experience disability due to illness or injury. Day rehabilitation may have advantages for families and healthcare systems over inpatient models of rehabilitation.
Research
CFTR-dependent defect in alternatively-activated macrophages in cystic fibrosisCFTR-dependent imbalance of macrophage phenotypes and functions could contribute to the exaggerated inflammatory response seen in CF lung disease
Research
Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-upThis study found that differences in regional grey matter volume are discernible at an early stage of ultra-high risk psychosis
Research
In Epigenomic Studies, Including Cell-Type Adjustments in Regression Models Can Introduce Multicollinearity, Resulting in Apparent Reversal of Direction of AssociationWhere cell types are highly correlated with other covariates in regression models, the statistical assumption of no multicollinearity may be violated
News & Events
The Kids pays tribute to Telethon pioneerThe Board and staff of The Kids Research Institute Australia are mourning the passing of former Institute Board member and supporter Sir James Cruthers.
News & Events
New blueprint for child health researchDelivering tangible and measurable improvements to the health and wellbeing of children is at the centre of a bold new blueprint for child health research in WA
News & Events
Chronic lung disease link targeted in new research studyA link between chronic lung disease and low Vitamin D levels is the focus of a new study just started by the Telethon Institute for Child Health Research.
News & Events
Be on alert for meningitisThe Meningitis Centre is urging all people to be on alert for the signs and symptoms of the potential deadly disease.
CliniKids is a not-for-profit centre integrating world-class research with a clinical service for children with developmental delay and/or autism, and their families. It is the first of its kind for autism in Australia.