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Chronic cat allergen exposure induces a Th2 cell-dependent IgG4 response related to low sensitization

This study evaluated the relationship between cat allergen–specific biomarkers in adults with cat allergy with and without cat ownership.

Environmental Factors in Children's Asthma and Respiratory Effects

Asthma is more common in childhood than in adulthood and is more correctly thought of as a syndrome than as a discrete condition.

Insights into respiratory disease through bioinformatics

Here, we review the basic concepts in bioinformatics and genomic data analysis and illustrate the application of these tools to further our understanding of lung diseases

Basophil counts in PBMC populations during childhood acute wheeze/asthma are associated with future exacerbations

Our findings suggest that the proportion of degranulated basophils can also be associated with recurrent exacerbations

Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease

To complement early allergic sensitization, monitoring NPM composition may enable early detection and intervention in high-risk children

IFNβ inhibits the development of allergen tolerance and is conducive to the development of asthma on subsequent allergen exposure

Data indicate a role for Interferonβ in linking viral infection and allergy

Prevalence of allergic sensitization, hay fever, eczema, and asthma in a longitudinal birth cohort

The aim of this study was to longitudinally assess the prevalence of allergic sensitization, asthma, eczema and hay fever from infancy to adulthood

Airway Interleukin-33 and type 2 cytokines in adult patients with acute asthma

Airway interleukin-33 is associated with type-2 cytokines in naturally occurring asthma exacerbations in adults

Effects of human rhinovirus on epithelial barrier integrity and function in children with asthma

This study demonstrates novel intrinsic differences in tight junctions gene and protein expression between airway epithelial cells of children with and without asthma

Asthma is responsible for considerable global morbidity and health-care costs. Substantial progress was made against key outcomes such as hospital admissions with asthma and mortality in the 1990s and early 2000s, but little improvement has been observed

We aim to provide our view of where we are and where we need to go as a community of clinicians and researchers who tackle the public health problem of asthma.