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Upper and lower airways are conserved in their transcriptional composition, and variations associated with disease are present in both nasal and tracheal epithelium
We identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues
Here we focus on the problem of prioritising variants with respect to the observed disease phenotype
Our results identify a pretreatment tumor microenvironment that predicts response to immune checkpoint blockade, which can be therapeutically attained
Our result highlighted that miRNA-target gene network contributes to human disease genetics in a cell type-specific manner
Epigenetic changes at the GFI1 were linked to smoking exposure in-utero/in-adulthood and robustly associated with cardio-metabolic risk factors
A better understanding of the innate immune responses by CF airway epithelial cells is needed to identify why viral infections are more severe in CF
A comprehensive picture of the regulatory regions of the three genes involved in Rett Syndrome
Feilman Fellow; Head, Precision Health Research and Head, Translational Intelligence
The immunological changes underpinning acquisition of remission (also called sustained unresponsiveness) following food immunotherapy remain poorly defined. Limited access to effective therapies and biosamples from treatment responders has prevented progress. Probiotic peanut oral immunotherapy is highly effective at inducing remission, providing an opportunity to investigate immune changes.