Impaired interferon response and allergic sensitization may contribute to virus-induced wheeze and asthma development in young children. Plasmacytoid…
Human perinatal life is characterized by a period of extraordinary change during which newborns encounter abundant environmental stimuli and exposure…
Atopic dermatitis is a common inflammatory skin condition and prior genome-wide association studies have identified 71 associated loci. In the curren…
Rhinoviruses (RVs) can cause severe wheezing illnesses in young children and patients with asthma. Vaccine development has been hampered by the multi…
Asthma exacerbations in children are associated with respiratory viral infection and atopy, resulting in systemic immune activation and infiltration…
Poor maternal diet during pregnancy is a risk factor for severe lower respiratory infections in the offspring, but the underlying mechanisms remain e…
Appropriate innate immune function is essential to limit pathogenesis and severity of severe lower respiratory infections (sLRI) during infancy, a le…
Results from recent clinical studies suggest potential efficacy of immune training (IT)-based approaches for protection against severe lower respirat…
Research question: Are asthma and allergies more common in adolescents conceived with assisted reproductive technologies (ART) compared with adolesce…
The immunological changes underpinning acquisition of remission (also called sustained unresponsiveness) following food immunotherapy remain poorly d…