Empirical Antibiotic Activity and Outcomes in Pediatric Gram-negative Bloodstream Infections: A Rank-based Composite Outcome Analysis

Citation:
Wen SCH, Hardy MJ, Aslan AT, Blyth CC, Britton PN, ……. Wadia U, Schlapbach L, ….. Richmond P et al. Empirical Antibiotic Activity and Outcomes in Pediatric Gram-negative Bloodstream Infections: A Rank-based Composite Outcome Analysis. Clinical infectious diseases. 2026;83(2):e282-e90

Keywords:
Gram-negative; antimicrobial therapy; bloodstream infections; outcome; pediatric

Abstract:
Timely active empirical therapy (AET) may improve outcomes following bloodstream infection. In high-income settings, low pediatric mortality following gram-negative bloodstream infection (GNBSI) limits its value as a sole endpoint. Composite measures that incorporate multiple clinically relevant outcomes may detect differences more readily. We assessed the effect of AET on clinical outcomes in pediatric GNBSI.