Skip to content
The Kids Research Institute Australia logo

LYL1 is critical for adult hematopoietic stem cell-derived B and T lymphopoiesis

Hematopoietic stem cells are defined by their remarkable self-renewal and differentiation capacities, giving rise to progenitors that generate diverse blood and immune cell lineages through the tightly regulated process of hematopoiesis. This process is governed by key transcription factors that control gene expression programs essential for cellular homeostasis, differentiation, and lineage commitment. 

Citation:
Chiu SK, The J, Saw J, et al. LYL1 is critical for adult hematopoietic stem cell-derived B and T lymphopoiesis. Sci Rep. 2026;16(1).

Keywords:
B-lymphocytes; T-lymphocytes; cytology; metabolism; helix proteins; cell lineage; genetics; neoplasm proteins;

Abstract:
Hematopoietic stem cells are defined by their remarkable self-renewal and differentiation capacities, giving rise to progenitors that generate diverse blood and immune cell lineages through the tightly regulated process of hematopoiesis. This process is governed by key transcription factors that control gene expression programs essential for cellular homeostasis, differentiation, and lineage commitment.