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SARS-CoV-2 Ancestral and Omicron variant immunity in Australian children in 2023, a seroprevalence study

The emergence of the SARS-CoV-2 Omicron variant in late 2021 led to widespread infection in Australian children, many unvaccinated. The breadth and magnitude of antibody responses to SARS-CoV-2 variant infections and vaccination in children remain incompletely understood. We aimed to estimate seroprevalence against SARS-CoV-2 spike (S) and nucleocapsid (N) antigens and explore antibody kinetics, focusing on Omicron subvariants.

Citation:
Koirala A, Prasad SA, Tjiam MC, Britton PN, Tedja C, Downes M, Skowno J, Wadia UD, Blyth CC, Crawford NW, ……. von Ungern-Sternberg BS, Archer PL, ……. Ong MM, Tansil S, Thornton RB, McMinn A, Hunter G, ……. Richmond P, Macartney K. SARS-CoV-2 Ancestral and Omicron variant immunity in Australian children in 2023, a seroprevalence study. Vaccine. 2026;85:128705.

Keywords:
Antibody; COVID-19; Children; SARS-CoV-2; Serosurveillance; Serosurvey

Abstract:
The emergence of the SARS-CoV-2 Omicron variant in late 2021 led to widespread infection in Australian children, many unvaccinated. The breadth and magnitude of antibody responses to SARS-CoV-2 variant infections and vaccination in children remain incompletely understood. We aimed to estimate seroprevalence against SARS-CoV-2 spike (S) and nucleocapsid (N) antigens and explore antibody kinetics, focusing on Omicron subvariants.