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The impact of genetics and the environment on cancer risk in Indigenous Australians: a narrative review

Aboriginal and Torres Strait Islander (hereafter respectfully named Indigenous) Australians are diagnosed with some cancers substantially more frequently than non-Indigenous Australians implying a different risk factor landscape. Additionally, poorer outcomes for certain cancers are exacerbated by lower cancer screening rates and later diagnoses compared to non-Indigenous Australians.

Citation:
Nguyen ADK, Meehan K, Redfern AD, Brown A, Robinson M, et al. The impact of genetics and the environment on cancer risk in Indigenous Australians: a narrative review. Lancet Reg Health West Pac. 2025.

Keywords:
Cancer; Social determinants; Indigenous health; Aboriginal and Torres Strait Islander health; Australia
Rural health; Cancer screening; Cancer risk

Abstract:
Aboriginal and Torres Strait Islander (hereafter respectfully named Indigenous) Australians are diagnosed with some cancers substantially more frequently than non-Indigenous Australians implying a different risk factor landscape. Additionally, poorer outcomes for certain cancers are exacerbated by lower cancer screening rates and later diagnoses compared to non-Indigenous Australians.