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Novel GABAAR antagonists target networked gene hubs at the leading-edge in high-grade gliomas

Ion channel activity underlying biological processes that drive high-grade gliomas (HGG) is largely unknown. We aimed to determine the networking of ion channel genes and validate their expression within HGG patient tumors, to identify ion channel-targeting drugs that would inhibit tumor-promoting processes.

Citation:
Shard C, Jones AC, Fouladzadeh A, Palethorpe HM, Francis A, Boyle Y, Ormsby RJ, Dewdney B, Yeow Y, Mahajan I, Barker M, Kuznetsova I, Jones ME, Patil A, Rezaeiravesh S, Ying Ng Z, Poonnoose SI, Bosco A, Valvi S, Forrest ARR, Johns TG, Gomez GA, Fletcher EV. Novel GABAAR antagonists target networked gene hubs at the leading-edge in high-grade gliomas. Neuro-Oncology. 2025.

Keywords:
GABAARs; WGCNA; high-grade glioma; leading-edge; synapse.

Abstract:
Ion channel activity underlying biological processes that drive high-grade gliomas (HGG) is largely unknown. We aimed to determine the networking of ion channel genes and validate their expression within HGG patient tumors, to identify ion channel-targeting drugs that would inhibit tumor-promoting processes.