Sex assigned at birth may modify health-related quality of life in children treated with peanut oral immunotherapy

The high burden of peanut allergy underscores the need for treatment options that improve patient health-related quality of life (HRQL). However, the modifying effect of sex assigned at birth on treatment-related outcomes remains poorly understood. We sought to investigate whether sex modifies treatment effect on the change in overall and subdomain HRQL during the PPOIT-003 trial.

Citation:
Rosser SA, Lloyd M, Loke P, …… O'Sullivan MD, Quinn P, et al. Sex assigned at birth may modify health-related quality of life in children treated with peanut oral immunotherapy. Pediatr Allergy Immunol. 2025;36(8).

Keywords:
Effect modification; food allergy; oral immunotherapy; quality of life

Abstract:
The high burden of peanut allergy underscores the need for treatment options that improve patient health-related quality of life (HRQL). However, the modifying effect of sex assigned at birth on treatment-related outcomes remains poorly understood. We sought to investigate whether sex modifies treatment effect on the change in overall and subdomain HRQL during the PPOIT-003 trial.