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Transmission potential of Streptococcus pyogenes during a controlled human infection trial of pharyngitis

Controlled human infection (CHI) models can provide insights into transmission of pathogens such as Streptococcus pyogenes (Strep A). As part of the Controlled Human Infection with Penicillin for Streptococcus pyogenes (CHIPS) trial, we explored the potential for transmission among participants deliberately infected with the Strep A emm75 strain.

Citation:
Enkel SL, Wong B, Hla TK, Pickering J, Barnett TC, Thomas HMM, Lansbury N, Carapetis JR, Osowicki J, Steer A, Manning L, Bowen AC. Transmission potential of Streptococcus pyogenes during a controlled human infection trial of pharyngitis. mSphere. 2024;9(10):e0051324.

Keywords:
Streptococcus pyogenes; acute rheumatic fever; environmental transmission of microbes; human infection study; infection control; infection prevention; infection transmission; rheumatic heart disease

Abstract:
Controlled human infection (CHI) models can provide insights into transmission of pathogens such as Streptococcus pyogenes (Strep A). As part of the Controlled Human Infection with Penicillin for Streptococcus pyogenes (CHIPS) trial, we explored the potential for transmission among participants deliberately infected with the Strep A emm75 strain.