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Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation

Neonatal sepsis is a deadly disease with non-specific clinical signs, delaying diagnosis and treatment. There remains a need for early biomarkers to facilitate timely intervention. Our objective was to identify neonatal sepsis gene expression biomarkers that could predict sepsis at birth, prior to clinical presentation. 

Citation:
An AY, Acton E, Idoko OT, Shannon CP, ……. Martino D, Tebbutt SJ, Levy O, Steen H, Kollmann TR, Kampmann B,  et al for the EPIC Consortium. Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation. eBioMedicine. 2024.

Keywords:
Machine learning; Neonatal sepsis; Ontogeny; Predictive biomarkers; Transcriptomics

Abstract:
Neonatal sepsis is a deadly disease with non-specific clinical signs, delaying diagnosis and treatment. There remains a need for early biomarkers to facilitate timely intervention. Our objective was to identify neonatal sepsis gene expression biomarkers that could predict sepsis at birth, prior to clinical presentation.