Early nasal microbiota and subsequent respiratory tract infections in infants with cystic fibrosis

Respiratory tract infections (RTIs) drive lung function decline in children with cystic fibrosis (CF). While the respiratory microbiota is clearly associated with RTI pathogenesis in infants without CF, data on infants with CF is scarce. We compared nasal microbiota development between infants with CF and controls and assessed associations between early-life nasal microbiota, RTIs, and antibiotic treatment in infants with CF.

Citation:
Steinberg R, Mostacci N, Kieninger E, .,…… Ramsey KA, Hilty M, Latzin P, Korten I. Early nasal microbiota and subsequent respiratory tract infections in infants with cystic fibrosis. Commun Med. 2024;4(1).

Keywords:
Respiratory tract infections; cystic fibrosis; microbiota; antibiotic treatment

Abstract:
Respiratory tract infections (RTIs) drive lung function decline in children with cystic fibrosis (CF). While the respiratory microbiota is clearly associated with RTI pathogenesis in infants without CF, data on infants with CF is scarce. We compared nasal microbiota development between infants with CF and controls and assessed associations between early-life nasal microbiota, RTIs, and antibiotic treatment in infants with CF.