Absence of association between maternal adverse events and long-term gut microbiome outcomes in the Australian autism biobank

Maternal immune activation and prenatal maternal stress are well-studied risk factors for psychiatric conditions such as autism and schizophrenia. Animal studies have proposed the gut microbiome as a mechanism underlying this association and have found that risk factor-related gut microbiome alterations persist in the adult offspring.

Citation:
Vasileva S, Yap CX, Whitehouse AJO, Gratten J, Eyles D. Absence of association between maternal adverse events and long-term gut microbiome outcomes in the Australian autism biobank. Brain, Behav, Immun - Health. 2024;39.

Keywords:
Gut microbiome; Maternal immune activation; Maternal stress; Prenatal risk factors; Autism spectrum disorders

Abstract:
Maternal immune activation and prenatal maternal stress are well-studied risk factors for psychiatric conditions such as autism and schizophrenia. Animal studies have proposed the gut microbiome as a mechanism underlying this association and have found that risk factor-related gut microbiome alterations persist in the adult offspring.