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Spatio-temporal spread of artemisinin resistance in Southeast Asia

Current malaria elimination targets must withstand a colossal challenge-resistance to the current gold standard antimalarial drug, namely artemisinin derivatives. If artemisinin resistance significantly expands to Africa or India, cases and malaria-related deaths are set to increase substantially.

Citation:
Flegg JA, Kandanaarachchi S, Guerin PJ, ……… Golding N. Spatio-temporal spread of artemisinin resistance in Southeast Asia. PLoS Comput Biol. 2024;20(4).

Keywords:
Malaria; antimalarials; artemisinins; epidemiology; pharmacology; parasitology; genetics

Abstract:
Current malaria elimination targets must withstand a colossal challenge-resistance to the current gold standard antimalarial drug, namely artemisinin derivatives. If artemisinin resistance significantly expands to Africa or India, cases and malaria-related deaths are set to increase substantially.