Keywords:
Adipose tissue; Airway hyper-responsiveness; Airway remodelling; Asthma; Bronchoconstriction; Obesity
Abstract:
Obesity is a contributing factor to asthma severity; while it has long been understood that obesity is related to greater asthma burden, the mechanisms though which this occurs have not been fully elucidated. One common explanation is that obesity mechanically reduces lung volume through accumulation of adipose tissue external to the thoracic cavity.