Down syndrome and leukemia: from basic mechanisms to clinical advances

Children with Down syndrome (DS, trisomy 21) are at a significantly higher risk of developing acute leukemia compared to the overall population. Many studies investigating the link between trisomy 21 and leukemia initiation and progression have been conducted over the last two decades.

Citation:
Baruchel A, Bourquin JP, Crispino J, …….. Malinge S, Rabin KR, et al. Down syndrome and leukemia: from basic mechanisms to clinical advances. Haematologica. 2023;108(10):2570-81.

Keywords:
Acute Disease; Down Syndrome; France; Leukemia; Myeloid; Precursor Cell; Lymphoblastic; Leukemia-Lymphoma; Genetics

Abstract:
Children with Down syndrome (DS, trisomy 21) are at a significantly higher risk of developing acute leukemia compared to the overall population. Many studies investigating the link between trisomy 21 and leukemia initiation and progression have been conducted over the last two decades.