Citation:
Rodrigo MKD, Saiganesh A, Hayes AJ, Wilson AM, Anstey J, Pickering JL, Iwasaki J, Hillas J, Winslow S, Woodman T, Nitschke P, Lacey JA, Breese KJ, van der Linden MPG, Giffard PM, Tong SYC, Gray N, Stubbs KA, Carapetis JR, Bowen AC, Davies MR, Barnett TC. Host-dependent resistance of Group A Streptococcus to sulfamethoxazole mediated by a horizontally-acquired reduced folate transporter. Nature Communications. 2022;13(1)
Keywords:
Bacterial DNA; dihydrofolate reductase; dihydropteroate synthase; folic acid; genomic DNA; messenger RNA; antimicrobial activity; antibiotic resistance; antibiotic sensitivity; Streptococcus pyogenes
Abstract:
Described antimicrobial resistance mechanisms enable bacteria to avoid the direct effects of antibiotics and can be monitored by in vitro susceptibility testing and genetic methods. Here we describe a mechanism of sulfamethoxazole resistance that requires a host metabolite for activity.