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A systems biology approach to better understand human tick-borne diseases

Tick-borne diseases are a growing global health concern. Despite extensive studies, ill-defined tick-associated pathologies remain with unknown aetiologies. Human immunological responses after tick bite, and inter-individual variations of immune-response phenotypes, are not well characterised.

Citation:
Lee W, Barbosa AD, Irwin PJ, Currie A, Kollmann TR, Beaman M, et al. A systems biology approach to better understand human tick-borne diseases. Trends Parasitol. 2022 Leukemia. 2022

Keywords:
Emerging diseases; multi-dimensional; network biology; systems biology; tick-borne diseases; tick–host–pathogen

Abstract:
Tick-borne diseases are a growing global health concern. Despite extensive studies, ill-defined tick-associated pathologies remain with unknown aetiologies. Human immunological responses after tick bite, and inter-individual variations of immune-response phenotypes, are not well characterised.