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Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life

Early life is marked by distinct and rapidly evolving immunity and increased susceptibility to infection. The vulnerability of the newborn reflects development of a complex immune system in the face of rapidly changing demands during the transition to extra-uterine life.

Citation:
Smolen KK, Plotkin AL, Shannon CP, Idoko OT, Amenyogbe, Kollmann TR… et al. Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life. Cytokine. 2021;148.

Keywords:
Chemokines; Cytokines; Infant immune; Innate immune; Ontogeny

Abstract:
Early life is marked by distinct and rapidly evolving immunity and increased susceptibility to infection. The vulnerability of the newborn reflects development of a complex immune system in the face of rapidly changing demands during the transition to extra-uterine life.