Variants associated with HHIP expression have sexdifferential effects on lung function

Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sexdifferential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females.

Citation:
Fawcett KA, Obeidat M, Melbourne C, Shrine N, …… Foong RE, Keidel D, Minelli, C, Langenberg C, ……. Hall GL, Sly PD, Pennell CE, et al. Variants associated with HHIP expression have sexdifferential effects on lung function. Wellcome Open Res. 2021;5:1-20.

Keywords:
Expression; genome-wide interaction study; HHIP; lung function; sex

Abstract:
Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sexdifferential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females.