Citation:
Fawcett KA, Wain LV, Obeidat M, Melbourne C, ....... Foong RE, Keidel D, Minelli C, ........ Hall GL, et al. Variants associated with HHIP expression have sex-differential effects on lung function. Wellcome Open Res. 2020;5.
Keywords:
HHIP; expression; genome-wide interaction study; lung function; sex
Abstract:
Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females.
Variants associated with HHIP expression have sex-differential effects on lung function
Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females.