SNAIL trail in myeloid malignancies

Transcription factors known to induce the epithelial-to-mesenchymal transition (EMT) (such as ZEB1/2 [zinc finger E-box binding homeobox 1/2], SNAI1/2/3, and TWIST1/2) have been undoubtedly implicated in tumorigenesis, cancer progression, metastasis, and chemoresistance in solid tumors; however, their role in normal and malignant hematopoiesis has been underappreciated for many years.

Citation:
Malinge S. SNAIL trail in myeloid malignancies. Blood. 2020;136(8):920-1.

Keywords:
Childhood cancer; leukaemia

Abstract:
Transcription factors known to induce the epithelial-to-mesenchymal transition (EMT) (such as ZEB1/2 [zinc finger E-box binding homeobox 1/2], SNAI1/2/3, and TWIST1/2) have been undoubtedly implicated in tumorigenesis, cancer progression, metastasis, and chemoresistance in solid tumors; however, their role in normal and malignant hematopoiesis has been underappreciated for many years. To date, the ZEB proteins are probably the most studied EMT regulators, since recurrent genetic alterations or deregulated expression of ZEB1 and ZEB2 genes has been reported in several subtypes of lymphoma, as well as in lymphoid and myeloid leukemia.