Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers

Acute erythroleukemia (AEL or acute myeloid leukemia [AML]-M6) is a rare but aggressive hematologic malignancy. Previous studies showed that AEL leukemic cells often carry complex karyotypes and mutations in known AML-associated oncogenes.

Citation:
Fagnan A, Bagger FO, Pique-Borras MR, ....... Malinge S, de Botton S, Micol JB et al. Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers. Blood. 2020;136(6):698-714.

Keywords:
RNA sequence; Leukemia, Erythroblastic, Acute/*genetics; DNA-Binding; Genetic Heterogeneity; Proteins/deficiency/genetics/physiology; Cell Transformation, Neoplastic/genetics

Abstract:
Acute erythroleukemia (AEL or acute myeloid leukemia [AML]-M6) is a rare but aggressive hematologic malignancy. Previous studies showed that AEL leukemic cells often carry complex karyotypes and mutations in known AML-associated oncogenes.