Authors:
Haggar FA, Pereira G, Preen D, D'Arcy Holman C, Einarsdottir K
Authors notes:
PLoS ONE. 2014;9(12):e113292
Keywords:
Cancer, outcomes, pregnancy, birth, adolescent and young adult cancer
Abstract:
Our objective was to investigate obstetric and perinatal outcomes among female survivors of adolescent and young adult (AYA) cancers and their offspring.
Compared with the non-cancer group, female survivors of AYA cancer had an increased risk of threatened abortion, gestational diabetes, preeclampsia, post-partum hemorrhage, cesarean delivery, and maternal postpartum hospitalization >5 days, but no excess risk of threatened preterm delivery, antepartum hemorrhage, premature rupture of membranes, failure of labor to progress or retained placenta.
Their offspring had an increased risk of premature birth, low birth weight, fetal growth restriction, and neonatal distress indicated by low Apgar score (<7) at 1 minute, need for resuscitation or special care nursery admission.
Congenital abnormalities and perinatal deaths (intrauterine or ≤7 days of birth) were not increased among offspring of survivors.
Female survivors of AYA cancer have moderate excess risks of adverse obstetric and perinatal outcomes arising from subsequent pregnancies that may require additional surveillance or intervention.