Authors:
Davey RJ, Howe W, Paramalingam N, Ferreira LD, Davis EA, Fournier PA, Jones TW
Authors notes:
Journal of Clinical Endocrinology and Metabolism. 2013;98(7):2908-2914
Keywords:
Glucose requirement, euglycemia, hypoglycaemia, exercise, time of day
Abstract:
Exercise increases the risk of hypoglycemia in type 1 diabetes.
Recently we reported a biphasic increase in glucose requirements to maintain euglycemia after late-afternoon exercise, suggesting a unique pattern of delayed risk for nocturnal hypoglycemia.
This study examined whether this pattern of glucose requirements occurs if exercise is performed earlier in the day.
Glucose infusion rates (GIR) to maintain euglycemia were not significantly different between groups at baseline and did not change in the rest condition throughout the study.
In contrast, GIR increased more than 3-fold during exercise, fell within the first hour of recovery, but remained elevated until 11 hours after exercise before returning to baseline levels.
The pattern of glucose requirements to maintain euglycemia in response to moderate-intensity exercise performed at midday suggests that the risk of exercise-mediated hypoglycemia increases during and for several hours after moderate-intensity exercise, with no evidence of a biphasic pattern of postexercise risk of hypoglycemia.