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Acute hyperglycaemia does not alter nitric oxide-mediated microvascular function in the skin of adolescents with type 1 diabetes

We assessed the impact of an acute bout of hyperglycaemia on nitric oxide (NO)-mediated microvascular function in the skin of adolescents with type 1...

Authors:
Naylor LH, Yusof NM, Paramalingam N, Jones TW, Davis EA

Authors notes:
European Journal of Applied Physiology. 2013;online:1-7

Keywords:
Adolescent, Blood glucose, Diabetes, Endothelial function, Microvessel, Skin blood flow

Abstract:
We assessed the impact of an acute bout of hyperglycaemia on nitric oxide (NO)-mediated microvascular function in the skin of adolescents with type 1 diabetes (T1DM).

In the hyperglycaemic group, acute increase in BGL was not associated with changes in skin blood flow or the contribution of NO to vasodilation.

These results suggest that, in our group of adolescents with type 1 diabetes, acute hyperglycaemia did not affect skin microvascular NO-mediated function.