Authors:
Le Page MEL, Goodridge JP, Zhang G, Holt PG, Sly P, Witt CS
Authors notes:
Tissue Antigens. 2013:online
Keywords:
Asthma, Atopy, CD158d, KIR2DL4
Abstract:
Human leukocyte antigen (HLA)-G is upregulated on the bronchial epithelium of asthma patients and genetic polymorphism affecting expression of HLA-G has been reported to influence susceptibility to asthma.
As the NK cell receptor KIR2DL4 has been reported to induce interferon gamma (IFNγ) secretion when ligated with HLA-G, we postulated that the 9A/10A genetic polymorphism of KIR2DL4 which influences receptor structure may influence susceptibility to asthma.
KIR2DL4 genotypes were determined in two cohorts of children in whom total serum IgE, allergen-specific IgE, atopy, bronchial reactivity and asthma symptoms had been studied between birth and 14years.
No reproducible associations with KIR2DL4 genotype were identified, leading us to conclude that the KIR2DL4 9A/10A polymorphism has no influence on susceptibility to asthma.