Polymorphisms associated with normal memory variation also affect memory impairment in schizophrenia

Neurocognitive dysfunction is a core feature of schizophrenia with particularly prominent deficits in verbal episodic memory.

Authors:
Jablensky A, Morar B, Wiltshire S, Carter K, Dragovic M, Badcock JC, Chandler D, Peters K, Kalaydjieva L

Authors notes:
Genes Brain Behav. 2011 Jun;10(4):410-7. doi: 10.1111/j.1601-183X.2011.00679.x. Epub 2011 Feb 10.

Keywords:
Polymorphisms associated with normal memory variation also affect memory impairment in schizophrenia

Abstract:
Neurocognitive dysfunction is a core feature of schizophrenia with particularly prominent deficits in verbal episodic memory. The molecular basis of this memory impairment is poorly understood and its relatedness to normal variation in memory performance is unclear. In this study, we explore, in a sample of cognitively impaired schizophrenia patients, the role of polymorphisms in seven genes recently reported to modulate episodic memory in normal subjects