Silencing of TESTIN by dense biallelic promoter methylation

Aberrant promoter DNA methylation has been reported in childhood acute lymphoblastic leukaemia and has the potential to contribute to its onset and outcome

Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia

Authors:
Weeks RJ, Kees UR, Song S, Morison IM.

Authors notes:
Mol Cancer. 2010 Jun 24;9:163.

Keywords:
silencing, TESTIN, dense biallelic promoter methylation, most common molecular event, childhood acute lymphoblastic leukaemia

Abstract:
Aberrant promoter DNA methylation has been reported in childhood acute lymphoblastic leukaemia (ALL) and has the potential to contribute to its onset and outcome. However, few reports demonstrate consistent, prevalent and dense promoter methylation, associated with tumour-specific gene silencing. By screening candidate genes, we have detected frequent and dense methylation of the TESTIN (TES) promoter.