Wal-yan Respiratory Research Centre
Team
Respiratory Environmental Health projects
Reports and Findings
Treatment with inhaled aerosolised ethanol reduces viral load and potentiates macrophage responses in an established influenza mouse model
Treatment options for viral lung infections are currently limited. We aimed to explore the safety and efficacy of inhaled ethanol in an influenza-infection mouse model.
Published research Pregnancy and Early Life Immunology Airway Epithelial Research P4 Respiratory Health for Kids Respiratory Environmental Health Bacterial Respiratory Infectious Disease Group Subsite: Walyan BREATHAdipose tissue in the small airways: How much is enough to drive functional changes?
Obesity is a contributing factor to asthma severity; while it has long been understood that obesity is related to greater asthma burden, the mechanisms though which this occurs have not been fully elucidated. One common explanation is that obesity mechanically reduces lung volume through accumulation of adipose tissue external to the thoracic cavity.
Asthma Published research Respiratory Environmental Health Subsite: WalyanStiffness Mediated-Mechanosensation of Airway Smooth Muscle Cells on Linear Stiffness Gradient Hydrogels
In obstructive airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), the extracellular matrix (ECM) protein amount and composition of the airway smooth muscle (ASM) is often remodelled, likely altering tissue stiffness. The underlying mechanism of how human ASM cell (hASMC) mechanosenses the aberrant microenvironment is not well understood.
Asthma Published research Respiratory Environmental Health Subsite: Walyan Lung functionA rapid semi-quantitative screening method to assess chemicals present in heated e-liquids and e-cigarette aerosols
Electronic cigarettes (e-cigarettes) lack regulatory status as therapeutic products in all jurisdictions worldwide. They are potentially unsafe consumer products, with significant evidence they pose a risk to human health. Therefore, developing rapid, economical test methods to assess the chemical composition of e-liquids in heated and unheated forms and the aerosols produced by e-cigarettes is crucial.
Published research Respiratory Environmental Health Subsite: Walyan Perioperative Medicine E-cigarettes