Wal-yan Respiratory Research Centre
WAERP
Team
Airway Epithelial Research projects
Reports and Findings
Treatment with inhaled aerosolised ethanol reduces viral load and potentiates macrophage responses in an established influenza mouse model
Treatment options for viral lung infections are currently limited. We aimed to explore the safety and efficacy of inhaled ethanol in an influenza-infection mouse model.
Published research Pregnancy and Early Life Immunology Airway Epithelial Research P4 Respiratory Health for Kids Respiratory Environmental Health Bacterial Respiratory Infectious Disease Group Subsite: Walyan BREATHImmune checkpoint therapy responders display early clonal expansion of tumor infiltrating lymphocytes
Immune checkpoint therapy (ICT) causes durable tumour responses in a subgroup of patients, but it is not well known how T cell receptor beta (TCRβ) repertoire dynamics contribute to the therapeutic response.
Children's Cancers Computational Biology Airway Epithelial Research Sarcoma Translational Research Subsite: Walyan Translational GeneticsThoracic Society of Australia and New Zealand position statement: The safe clinical use of sputum induction for bio-sampling of the lower airways in children and adults
Sputum induction is widely used in clinical settings for collection of biological samples from the lower airways. However, in recent years sputum induction has been associated with serious adverse events and even death. This position statement was commissioned by the Thoracic Society of Australia and New Zealand to address major adverse events of two deaths associated with sputum induction that have occurred in Australia in 2021, and outlines best practice for the safe use of sputum induction.
Published research Airway Epithelial Research Subsite: Walyan BREATHEarly treatment with fluvoxamine, bromhexine, cyproheptadine, and niclosamide to prevent clinical deterioration in patients with symptomatic COVID-19: a randomized clinical trial
Repurposed drugs with host-directed antiviral and immunomodulatory properties have shown promise in the treatment of COVID-19, but few trials have studied combinations of these agents. The aim of this trial was to assess the effectiveness of affordable, widely available, repurposed drugs used in combination for treatment of COVID-19, which may be particularly relevant to low-resource countries.
Published research Immunisation Infectious Diseases Airway Epithelial Research Subsite: Walyan COVID-19 Immunology and Breast Feeding