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Research

Revisiting the inoculum effect for Streptococcus pyogenes with a hollow fibre infection model

Severe, invasive Streptococcus pyogenes (Strep A) infections result in greater than 500,000 deaths annually. First line treatment for such infections is benzylpenicillin, often with the addition of clindamycin, but treatment failure can occur with this regimen. This failure has been partially attributed to the inoculum effect, which presents as reduced antibiotic susceptibility during high bacterial density and plateau-phase growth.

Research

Prospective surveillance of primary healthcare presentations for scabies and bacterial skin infections in Fiji, 2018-2019

Scabies, impetigo, and other skin and soft tissue infections (SSTIs) are highly prevalent in many tropical, low-middle income settings, but information regarding their burden of disease is scarce. We conducted surveillance of presentations of scabies and SSTIs, including impetigo, abscesses, cellulitis, and se≈vere SSTI, to primary health facilities in Fiji.

Research

Adjunctive protein synthesis inhibitor antibiotics for toxin suppression in Staphylococcus aureus infections: a systematic appraisal

A summary of the literature regarding the use of adjunctive protein synthesis inhibitors for toxin suppression in the setting of S. aureus infections is presented

Research

Characterising the SARS-CoV-2 nucleocapsid (N) protein antibody response

SARS-CoV-2 nucleocapsid (N) protein antibodies can be used to identify the serological response to natural infection in those who have previously received a COVID-19 spike-based vaccine. Anti-N antibody responses can also be induced by inactivated whole SARS-CoV-2 virus vaccines, such as CoronaVac. We aimed to characterise antibody responses to the N protein following COVID-19 and following vaccination with CoronaVac.

OPTIMUM Study

Contact us If you'd like to get in touch, please contact us by phone or email. Phone: 0400 450 240 Email: OPTIMUM@thekids.org.au   What is the 

Pneumococcal Disease

Contact us If you'd like to get in touch, please contact us by phone or email. Phone: 0400 450 240 Email: vtg@thekids.org.au Pneumococcal disease is

News & Events

Maths, modelling and RSV: the unique combo driving virus prevention

The Kids Research Institute developed a world-first RSV transmission model using real data to predict the impact of WA’s immunisation program for young children.

News & Events

Clinical trial recruiting babies for RSV and hMPV vaccine study

MEDIA ENQUIRIES Discover. Prevent. Cure. Mailing list Media contacts About The Kids Be Inspired Please direct general enquiries to our reception on (

News & Events

Study finds Covid-19 severity reduced for children

An international study examining Covid-19 severity on hospitalised children and adolescents has found that as the virus became more infectious, intensive care admissions dropped across multiple age groups regardless of vaccination status.

News & Events

Implants could replace painful injections to treat rheumatic heart disease

Painful monthly penicillin injections to treat and prevent Rheumatic Heart Disease (RHD) could be replaced with a longer-acting implant, a recent study has found.