Investigators: Rishi Kotecha, Laurence Cheung, Sebastien Malinge
Project description
Modern therapies for children with leukaemia are curative in more than 90%. In contrast, survival for infants less than one year of age at the time of diagnosis is less than 50%. Better therapies are desperately needed. From laboratory testing we have discovered effective novel cancer drugs, which are not currently used for the treatment of babies with leukaemia. This project uses patient cells grown in the laboratory. These cells are comprehensively tested for their drug responses against thousands of novel therapeutic agents. Promising candidate drugs are further investigated to precisely determine how they work to kill the cancer cells. These agents are then further tested for their potential use in patients using preclinical models we have developed onsite or through our collaborations.
Collaborators
- Ronald Stam (Princess Maxima Center Netherlands)
- Richard Lock (Children's Cancer Institute, Sydney)
Partners
- Children's Leukemia & Cancer Research Foundation (Inc.)
- The Kids Cancer Project