Investigators: Jonathan Carapetis, Joseph Kado, Rebecca Trowman, Tim Barnett
External collaborators: Ben Boyd (Monash Institute of Pharmaceutical Sciences), Cornelia Landersdorfer (Monash Institute of Pharmaceutical Sciences)
Aim 1: To determine the minimum inhibitory concentrations of penicillin G against a representative collection of Group A Streptococcus strains; and
Aim 2: To evaluate, in the hollow-fibre infection model, the impact of penicillin G concentration and size of bacterial inoculum on the prophylactic effect for Strep A strains with different characteristics.