Wal-yan Respiratory Research Centre
Team
Pregnancy and Early Life Immunology projects
Reports and Findings
Treatment with inhaled aerosolised ethanol reduces viral load and potentiates macrophage responses in an established influenza mouse model
Treatment options for viral lung infections are currently limited. We aimed to explore the safety and efficacy of inhaled ethanol in an influenza-infection mouse model.
Published research Pregnancy and Early Life Immunology Airway Epithelial Research P4 Respiratory Health for Kids Respiratory Environmental Health Bacterial Respiratory Infectious Disease Group Subsite: Walyan BREATHImpaired interferon response in plasmacytoid dendritic cells from children with persistent wheeze
Impaired interferon response and allergic sensitization may contribute to virus-induced wheeze and asthma development in young children. Plasmacytoid dendritic cells play a key role in antiviral immunity as critical producers of type I interferons.
Asthma Published research Pregnancy and Early Life Immunology Human Immunology Airway Epithelial Research Subsite: Wesfarmers Centre of Vaccines and Infectious Diseases Children’s Respiratory Science Lung functionEgg-sensitised infants have elevated CD4+ effector memory T regulatory cells from birth
IgE-mediated sensitisation to egg is common in infants. In some cases, the processes leading to egg sensitisation are established in early life, even before introduction to solid foods. The underlying mechanisms remain poorly understood.
Published research Pregnancy and Early Life Immunology Nutrition in Early Life ORIGINS Bacterial Respiratory Infectious Disease GroupEarly Peanut Immunotherapy in Children (EPIC) trial: Protocol for a pragmatic randomised controlled trial of peanut oral immunotherapy in children under 5 years of age
Food allergy is a major public health challenge in Australia. Despite widespread uptake of infant feeding and allergy prevention guidelines the incidence of peanut allergy in infants has not fallen, and prevalence of peanut allergy in school-aged children continues to rise. Therefore, effective and accessible treatments for peanut allergy are required.
Published research Pregnancy and Early Life Immunology Food Allergy